Jim Irwin , Apollo 15 . Donn Eisele , Apollo 7 . Ronald Evans , Apollo 17 . Wally Schirra , Apollo 7 . Neil Armstrong , Apollo 11 . These are all Apollo astronautswho diedof pump attacks or related complications . All distinguish , 43 percent of deceased cosmonaut from the Apollo missions died from cardiovascular problems , concord to a new studypublished today in Nature ’s Scientific Reports .

That ’s between four and five times high than astronauts who never flew on a mission or who never bequeath blue - Earth orbit . Michael Delp of Florida State University , moderate writer of the new study , believes the likely culprit of this higher rate is theirunprecedented exposure to inscrutable space radiation . This is in line witha 2014 paperthat declared space radiation therapy the routine one risk of exposure to cosmonaut wellness beyond the downcast - earth orbit .

In Irwin ’s event , flight surgeons noticed signaling of a spirit attack as the crew was transferring moon rocks from the lunar module into the command / table service faculty in 1971 . Had this happened on Earth , Irwin would have been rushed to the ICU . But the zero gravity surroundings of the moon , pure O , a pressure cause , and constant monitoring from ground control was almost as good as an ICU . And Irwin ’s heart rhythm soon return to normal . But a few month after returning to Earth , he suffered a eye attack . [ UPDATE : The first signs of trouble were in reach , not during a moonwalk , and Irwin in reality died in 1991 , also from a heart attempt . Thanks to eagle - eyed readers for pointing this out . ]

Argentina’s President Javier Milei (left) and Robert F. Kennedy Jr., holding a chainsaw in a photo posted to Kennedy’s X account on May 27. 2025.

There have been four prior studies of astronaut mortality , most of which in reality showed lower mortality rate rate compare to the world-wide population , particularly for cardiovascular problems and cancer . ( inadvertent destruction were higher for spaceman . ) Delp ’s group opt to focalize specifically on the Apollo astronauts , however .

He also used a unlike ascendency group . retiring studies drew on the general US population , especially people who lived near Johnson Space Center or work there . Delp take his controller group with cosmonaut who had never flown , culled from the Apollo , Gemini , and space shuttle programs , as well as two cancel Air Force space platform . This help weed out possible fox factors , grant that your average astronaut is far healthier than the universe at large .

Granted , it ’s a bantam sampling size . Only 24 men flew into deep blank space during the Apollo program , and of those , eight have died . Seven were included in the field of study ; Edgar Mitchelldied in February , after Delp and his colleagues had already completed their analysis . Delp acknowledge this defect , but it ’s not like there ’s any direction to increase the sample size . “ It ’s a problem in all of quad studies , ” he told Gizmodo . “ You just have to deal these findings with caution . ”

William Duplessie

Delp felt it was important to publish the data nonetheless , because the ISS will be decommissioned in 2024 , and several state ( including the US ) are devise for future manned mission to the lunar month and maybe Mars . If rich outer space radiation is having a damaging effect on astronauts ’ cardiovascular systems , the clock is ticking to figure out exactly what those effects are and how best to palliate them .

His squad has also performed experiment with mice . They move to Brookhaven National Laboratory , the only position where mice can be exposed to this specific type of radiation sickness . The character of radiation we experience on Earth is known to cause cardiovascular problems in mice , but at much higher doses than what astronauts are exposed to in mysterious space . But deep space radiation is much more damaging , even at much lower VD , so the inauspicious effects are potentially much greater .

Delp and his colleagues found that one group of mouse disclose to radiation therapy show signs of cardiovascular disease in the form of blocked arteries after six months — the equivalent of 20 human years . They compared this with a control mathematical group of mice that had been suspended by their hind legs to mime the physiological result of weightlessness , as well as chemical group of mice that had been exposed to both radiation and weightlessness .

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The results : Weightlessness had some negative upshot , but these wore off within six calendar month . Radiation also had early negative effects , and so did the combination of the two , except in those two grouping , the effect did n’t wear off . “ That says that the cardiovascular system can recuperate from lightness , even though it ’s an former burden , but the radiation syndrome effect are sustained , ” said Delp . The same looks like true for the Apollo astronauts .

Delp and his colleagues are already working with scientist at Johnson Space Center on a surveil - up survey to gather more elaborate data on the aesculapian background of the Apollo cosmonaut . Who had a household history of heart problems , or diabetes , and which of them were continuing smokers ? These are among the many discombobulate component that could also have contribute to the in high spirits pace of heart attacks .

We still do n’t know much about the untoward affect of deep space radiation on human health . But Delp ’s squad has give us a first glimpse into this complicated trouble — the respectable to prepare for the manned space missions to get .

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[ Nature Scientific Reports ]

Apollo programPhysicsScienceSpace

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